Hitchcock demanded a lot from her during the filming of The Birds, so much so that a doctor recommended that she rest for a week before resuming filming, much to the chagrin of Hitchcock. Hedren was signed with Hitchcock for seven years, and after butting heads even further during the filming of Marnie, Hedren decided to stop acting until her contract with Hitchcock expire. During that time, she became highly involved with animal shelters. In 1983, she found the animal rescue at Shambala Preserve, an 80-acre (320,000 m2) wildlife habitat.
Hedren is the mother of actress Melanie Griffith, with whom she shares credits on several productions, notably Pacific Heights (1990).